Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures

More efficient or translationally relevant approaches are needed to model acquired temporal lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding and maintaining transgenic, knock-in, or knock-out lines places a high value on the efficiency of induction and anima...

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Pubblicato in:Exp Neurol
Autori principali: Umpierre, Anthony D., Bennett, Isaiah V., Nebeker, Lismore D., Newell, Thomas G., Tian, Bruce B., Thomson, Kyle E., White, H. Steve, White, John A., Wilcox, Karen S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382800/
https://ncbi.nlm.nih.gov/pubmed/26896834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.02.014
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