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Expanding the 3-O-Sulfate Proteome—Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity

Binding of proteins to heparan sulfate is driven predominantly by electrostatic interactions between positively charged amino acid residues in the protein and negatively charged sulfate groups located at various positions along the polysaccharide chain. Although many heparin/heparan-sulfate-binding...

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Библиографические подробности
Опубликовано в: :ACS Chem Biol
Главные авторы: Thacker, Bryan E., Seamen, Emylie, Lawrence, Roger, Parker, Matthew W., Xu, Yongmei, Liu, Jian, Vander Kooi, Craig W., Esko, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450942/
https://ncbi.nlm.nih.gov/pubmed/26731579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00897
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