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Rare 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
Prion-like transcellular spreading of tau in Alzheimer’s Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. Microarray and SPR assays of structurally-defined HS oligosaccharides show that...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6982596/ https://ncbi.nlm.nih.gov/pubmed/31692167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913029 |
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