Wird geladen...
Rare 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
Prion-like transcellular spreading of tau in Alzheimer’s Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. Microarray and SPR assays of structurally-defined HS oligosaccharides show that...
Gespeichert in:
| Veröffentlicht in: | Angew Chem Int Ed Engl |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6982596/ https://ncbi.nlm.nih.gov/pubmed/31692167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913029 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|