Rare 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake

Prion-like transcellular spreading of tau in Alzheimer’s Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. Microarray and SPR assays of structurally-defined HS oligosaccharides show that...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Zhao, Jing, Zhu, Yanan, Song, Xuehong, Xiao, Yuanyuan, Su, Guowei, Liu, Xinyue, Wang, Zhangjie, Xu, Yongmei, Liu, Jian, Eliezer, David, Ramlall, Trudy F., Lippens, Guy, Gibson, James, Zhang, Fuming, Linhardt, Robert J., Wang, Lianchun, Wang, Chunyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982596/
https://ncbi.nlm.nih.gov/pubmed/31692167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913029
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