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Prion Protein Regulates Iron Transport by Functioning as a Ferrireductase
Prion protein (PrP(C)) is implicated in the pathogenesis of prion disorders, but its normal function is unclear. We demonstrate that PrP(C) is a ferrireductase (FR), and its absence causes systemic iron deficiency in PrP knock-out mice (PrP(−/−)). When exposed to non-transferrin-bound (NTB) radioact...
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| Pubblicato in: | J Alzheimers Dis |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5450724/ https://ncbi.nlm.nih.gov/pubmed/23478311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-130218 |
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