Prion Protein Promotes Kidney Iron Uptake via Its Ferrireductase Activity

Brain iron-dyshomeostasis is an important cause of neurotoxicity in prion disorders, a group of neurodegenerative conditions associated with the conversion of prion protein (PrP(C)) from its normal conformation to an aggregated, PrP-scrapie (PrP(Sc)) isoform. Alteration of iron homeostasis is believ...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Haldar, Swati, Tripathi, Ajai, Qian, Juan, Beserra, Amber, Suda, Srinivas, McElwee, Matthew, Turner, Jerrold, Hopfer, Ulrich, Singh, Neena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342466/
https://ncbi.nlm.nih.gov/pubmed/25572394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607507
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