A sensitivity analysis of RNA folding nearest neighbor parameters identifies a subset of free energy parameters with the greatest impact on RNA secondary structure prediction

Nearest neighbor parameters for estimating the folding energy changes of RNA secondary structures are used in structure prediction and analysis. Despite their widespread application, a comprehensive analysis of the impact of each parameter on the precision of calculations had not been conducted. To...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Zuber, Jeffrey, Sun, Hongying, Zhang, Xiaoju, McFadyen, Iain, Mathews, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449625/
https://ncbi.nlm.nih.gov/pubmed/28334976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx170
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