Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context

Cis-regulatory elements feature clustered sites for transcription factors, defining core enhancers and have inter-species homology. The mouse IgH 3΄ regulatory region (3’RR), a major B-cell super-enhancer, consists of four of such core enhancers, scattered throughout more than 25 kb of packaging ‘ju...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Le Noir, Sandrine, Boyer, François, Lecardeur, Sandrine, Brousse, Mylène, Oruc, Zeliha, Cook-Moreau, Jeanne, Denizot, Yves, Cogné, Michel
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449612/
https://ncbi.nlm.nih.gov/pubmed/28369649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx203
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