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5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation
5-Lipoxygenase (5LO) is involved in the production of leukotrienes and reactive oxygen species (ROS) from arachidonic acid. Its strong activation has been associated with several diseases like cancer and neurodegeneration. Here we show that 5LO activity increases during senescence-like growth arrest...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC544914/ https://ncbi.nlm.nih.gov/pubmed/15616590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600502 |
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