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Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
A critical step during human microRNA maturation is the processing of the primary microRNA transcript by the nuclear RNaseIII enzyme Drosha to generate the ∼60-nucleotide precursor microRNA hairpin. How Drosha recognizes primary RNA substrates and selects its cleavage sites has remained a mystery, e...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2005
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC544904/ https://ncbi.nlm.nih.gov/pubmed/15565168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600491 |
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