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Structural requirements for pre-microRNA binding and nuclear export by Exportin 5
The biogenesis and function of mature human microRNAs is dependent on the nuclear export of pre-microRNA precursors by Exportin 5 (Exp5). The precursor for the human miR-30 microRNA, which is a 63 nt long RNA hairpin bearing a 2 nt 3′ overhang, forms a specific complex with Exp5 and the Ran-GTP cofa...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC519115/ https://ncbi.nlm.nih.gov/pubmed/15356295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh824 |
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