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Structural requirements for pre-microRNA binding and nuclear export by Exportin 5

The biogenesis and function of mature human microRNAs is dependent on the nuclear export of pre-microRNA precursors by Exportin 5 (Exp5). The precursor for the human miR-30 microRNA, which is a 63 nt long RNA hairpin bearing a 2 nt 3′ overhang, forms a specific complex with Exp5 and the Ran-GTP cofa...

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Bibliografske podrobnosti
Main Authors: Zeng, Yan, Cullen, Bryan R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC519115/
https://ncbi.nlm.nih.gov/pubmed/15356295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh824
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