Novel small molecule inhibiting CDCP1‐PKCδ pathway reduces tumor metastasis and proliferation

CUB domain‐containing protein‐1 (CDCP1) is a trans‐membrane protein predominantly expressed in various cancer cells and involved in tumor progression. CDCP1 is phosphorylated at tyrosine residues in the intracellular domain by Src family kinases and recruits PKCδ to the plasma membrane through tyros...

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Détails bibliographiques
Publié dans:Cancer Sci
Auteurs principaux: Nakashima, Katsuhiko, Uekita, Takamasa, Yano, Shigenobu, Kikuchi, Jun‐ichi, Nakanishi, Ruri, Sakamoto, Nozomi, Fukumoto, Keisuke, Nomoto, Akihiro, Kawamoto, Keisuke, Shibahara, Takashi, Yamaguchi, Hideki, Sakai, Ryuichi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448658/
https://ncbi.nlm.nih.gov/pubmed/28256037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13218
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