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Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.

Pulmonary surfactant is produced in late gestation by developing type II epithelial cells lining the alveolar epithelium of the lung. Lack of surfactant at birth is associated with respiratory distress syndrome in premature infants. Surfactant protein C (SP-C) is a highly hydrophobic peptide isolate...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Korfhagen, T R, Glasser, S W, Wert, S E, Bruno, M D, Daugherty, C C, McNeish, J D, Stock, J L, Potter, S S, Whitsett, J A
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54484/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2385587/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.16.6122
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