Altered stability of pulmonary surfactant in SP-C-deficient mice

The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function, SP-C-deficient (−/−) mice were produced. The SP-C (−/−) mice were viable at birth and grew normally to adulthood witho...

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Main Authors: Glasser, Stephan W., Burhans, Michael S., Korfhagen, Thomas R., Na, Cheng-Lun, Sly, Peter D., Ross, Gary F., Ikegami, Machiko, Whitsett, Jeffrey A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC33474/
https://ncbi.nlm.nih.gov/pubmed/11344267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101500298
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