Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflammation, emphysema, and fibrosis in the lungs of SP-D (−/−) mice. Although lung morphology was unperturbed during the first 2 weeks of life, airspace enlargement was observed by 3 weeks and progressed with advancing age. I...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wert, Susan E., Yoshida, Mitsuhiro, LeVine, Ann Marie, Ikegami, Machiko, Jones, Tracy, Ross, Gary F., Fisher, James H., Korfhagen, Thomas R., Whitsett, Jeffrey A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10801980/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100448997
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