A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

BACKGROUND: The combination of everolimus and the imidazoquinoline derivative, BEZ235 (dactolisib), a dual PI3K/mTOR inhibitor, demonstrated synergy in a preclinical model. OBJECTIVE: To establish clinical feasibility, a phase Ib dose-escalation trial investigating safety and pharmacokinetics of thi...

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Udgivet i:Target Oncol
Main Authors: Wise-Draper, Trisha M., Moorthy, Ganesh, Salkeni, Mohamad A., Karim, Nagla Abdel, Thomas, Hala Elnakat, Mercer, Carol A., Beg, M. Shalaan, O’Gara, Sue, Olowokure, Olugbenga, Fathallah, Hassana, Kozma, Sara C., Thomas, George, Rixe, Olivier, Desai, Pankaj, Morris, John C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2017
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447332/
https://ncbi.nlm.nih.gov/pubmed/28357727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-017-0482-9
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