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Role of Munc13-4 as a Ca(2+)-dependent tether during platelet secretion
The Munc13 family of exocytosis regulators has multiple Ca(2+)-binding, C2 domains. Here, we probed the mechanism by which Munc13-4 regulates in vitro membrane fusion and platelet exocytosis. We show that Munc13-4 enhances in vitro SNARE-dependent, proteoliposome fusion in a Ca(2+)- and phosphatidyl...
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| Publicado no: | Biochem J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5446777/ https://ncbi.nlm.nih.gov/pubmed/26637270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151150 |
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