Role of Munc13-4 as a Ca(2+)-dependent tether during platelet secretion

The Munc13 family of exocytosis regulators has multiple Ca(2+)-binding, C2 domains. Here, we probed the mechanism by which Munc13-4 regulates in vitro membrane fusion and platelet exocytosis. We show that Munc13-4 enhances in vitro SNARE-dependent, proteoliposome fusion in a Ca(2+)- and phosphatidyl...

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Bibliografiska uppgifter
I publikationen:Biochem J
Huvudupphovsmän: Chicka, Michael C., Ren, Qiansheng, Richards, David, Hellman, Lance M., Zhang, Jinchao, Fried, Michael G., Whiteheart, Sidney W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446777/
https://ncbi.nlm.nih.gov/pubmed/26637270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151150
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