Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments

The NS2A protein of dengue virus (DENV) has eight predicted transmembrane segments (pTMS1 to -8) and participates in RNA replication, virion assembly, and host antiviral response. However, the roles of specific amino acid residues within the pTMS regions of NS2A during the viral life cycle are not c...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Wu, Ren-Huang, Tsai, Ming-Han, Tsai, Kuen-Nan, Tian, Jia Ni, Wu, Jian-Sung, Wu, Su-Ying, Chern, Jyh-Haur, Chen, Chun-Hong, Yueh, Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
Onderwerpen:
Genome Replication and Regulation of Viral Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446631/
https://ncbi.nlm.nih.gov/pubmed/28381578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01836-16
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