A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease

Dengue virus (DENV) causes disease globally, resulting in an estimated 25 to 100 million new infections per year. No effective DENV vaccine is available, and the current treatment is only supportive. Thus, there is an urgent need to develop therapeutic agents to cure this epidemic disease. In the pr...

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Bibliographic Details
Main Authors: Yang, Chi-Chen, Hu, Han-Shu, Wu, Ren-Huang, Wu, Szu-Huei, Lee, Shiow-Ju, Jiaang, Weir-Torn, Chern, Jyh-Haur, Huang, Zhi-Shun, Wu, Huey-Nan, Chang, Chung-Ming, Yueh, Andrew
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910792/
https://ncbi.nlm.nih.gov/pubmed/24145533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01281-13
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