DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection

BACKGROUND: A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance malaria control. DSM265 is an experimental antimalarial that selectively inhibits the parasite dihydroorotate dehydrogenase. DSM265 shows in vitro act...

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Vydáno v:Lancet Infect Dis
Hlavní autoři: Sulyok, Mihály, Rückle, Thomas, Roth, Alexandra, Mürbeth, Raymund E, Chalon, Stephan, Kerr, Nicola, Samec, Sonia Schnieper, Gobeau, Nathalie, Calle, Carlos Lamsfus, Ibáñez, Javier, Sulyok, Zita, Held, Jana, Gebru, Tamirat, Granados, Patricia, Brückner, Sina, Nguetse, Christian, Mengue, Juliana, Lalremruata, Albert, Sim, B Kim Lee, Hoffman, Stephen L, Möhrle, Jörg J, Kremsner, Peter G, Mordmüller, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science ;, The Lancet Pub. Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446410/
https://ncbi.nlm.nih.gov/pubmed/28363637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(17)30139-1
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