DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection

BACKGROUND: A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance malaria control. DSM265 is an experimental antimalarial that selectively inhibits the parasite dihydroorotate dehydrogenase. DSM265 shows in vitro act...

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Foilsithe in:Lancet Infect Dis
Main Authors: Sulyok, Mihály, Rückle, Thomas, Roth, Alexandra, Mürbeth, Raymund E, Chalon, Stephan, Kerr, Nicola, Samec, Sonia Schnieper, Gobeau, Nathalie, Calle, Carlos Lamsfus, Ibáñez, Javier, Sulyok, Zita, Held, Jana, Gebru, Tamirat, Granados, Patricia, Brückner, Sina, Nguetse, Christian, Mengue, Juliana, Lalremruata, Albert, Sim, B Kim Lee, Hoffman, Stephen L, Möhrle, Jörg J, Kremsner, Peter G, Mordmüller, Benjamin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier Science ;, The Lancet Pub. Group 2017
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446410/
https://ncbi.nlm.nih.gov/pubmed/28363637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(17)30139-1
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