Identification of Na(+)/K(+)-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

The current study explored the Na(+)/K(+)-ATPase (NKA) inhibition-independent proarrhythmic mechanisms of cardiac glycosides (CGs) which are well-known NKA inhibitors. With the cytosolic Ca(2+) chelated by EGTA and BAPTA or extracellular Ca(2+) replaced by Ba(2+), effects of bufadienolides (bufalin...

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Udgivet i:Sci Rep
Main Authors: Koh, Cai Hong, Wu, Jianjun, Chung, Ying Ying, Liu, Zhenfeng, Zhang, Rong-Rong, Chong, Ketpin, Korzh, Vladimir, Ting, Sherwin, Oh, Steve, Shim, Winston, Tian, Hai-Yan, Wei, Heming
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446409/
https://ncbi.nlm.nih.gov/pubmed/28550304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02496-4
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