20- HETE Signals Through G Protein-Coupled Receptor GPR75 (G(q)) to Affect Vascular Function and Trigger Hypertension

RATIONALE: 20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome P450 (CYP) eicosanoids, is a potent vasoactive lipid whose vascular effects include stimulation of smooth muscle contractility, migration and proliferation, as well as endothelial cell dysfunction and inflammation....

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Pubblicato in:Circ Res
Autori principali: Garcia, Victor, Gilani, Ankit, Shkolnik, Brian, Pandey, Varunkumar, Zhang, Frank Fan, Dakarapu, Rambabu, Gandham, Shyam K., Reddy, N. Rami, Graves, Joan P., Gruzdev, Artiom, Zeldin, Darryl C., Capdevila, Jorge H., Falck, John R., Schwartzman, Michal Laniado
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446268/
https://ncbi.nlm.nih.gov/pubmed/28325781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.310525
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