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Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation

The modulation of canonical macroautophagy/autophagy for therapeutic benefit is an emerging strategy of medical and pharmaceutical interest. Many drugs act to inhibit autophagic flux by targeting lysosome function, while others were developed to activate the pathway. Here, we report the surprising f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Jacquin, Elise, Leclerc-Mercier, Stéphanie, Judon, Celine, Blanchard, Emmanuelle, Fraitag, Sylvie, Florey, Oliver
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446083/
https://ncbi.nlm.nih.gov/pubmed/28296541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1287653
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