Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial

A potential therapeutic role for immune transformation in Parkinson’s disease evolves from more than a decade of animal investigations demonstrating regulatory T cell (Treg) nigrostriatal neuroprotection. To bridge these results to human disease, we conducted a randomized, placebo-controlled double-...

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Vydáno v:NPJ Parkinsons Dis
Hlavní autoři: Gendelman, Howard E., Zhang, Yuning, Santamaria, Pamela, Olson, Katherine E., Schutt, Charles R., Bhatti, Danish, Shetty, Bhagya Laxmi Dyavar, Lu, Yaman, Estes, Katherine A., Standaert, David G., Heinrichs-Graham, Elizabeth, Larson, LuAnn, Meza, Jane L., Follett, Matthew, Forsberg, Erica, Siuzdak, Gary, Wilson, Tony W., Peterson, Carolyn, Mosley, R. Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445595/
https://ncbi.nlm.nih.gov/pubmed/28649610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-017-0013-5
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