Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease

BACKGROUND: Neuroinflammation plays a pathogenic role in Parkinson's disease (PD). Immunotherapies that restore brain homeostasis can mitigate neurodegeneration by transforming T cell phenotypes. Sargramostim has gained considerable attention as an immune transformer through laboratory bench to...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Olson, Katherine E., Namminga, Krista L., Lu, Yaman, Schwab, Aaron D., Thurston, Mackenzie J., Abdelmoaty, Mai M., Kumar, Vikas, Wojtkiewicz, Melinda, Obaro, Helen, Santamaria, Pamela, Mosley, R. Lee, Gendelman, Howard E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138485/
https://ncbi.nlm.nih.gov/pubmed/34000620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103380
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