A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease

PURPOSE: Because of the evolutionary loss of the uricolytic pathway, humans accumulate poorly soluble urate as the final product of purine catabolism. Restoration of uricolysis through enzyme therapy is a promising treatment for severe hyperuricemia caused by deficiency of hypoxanthine-guanine phosp...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pharm Res
Egile Nagusiak: Ronda, Luca, Marchetti, Marialaura, Piano, Riccardo, Liuzzi, Anastasia, Corsini, Romina, Percudani, Riccardo, Bettati, Stefano
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer US 2017
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445154/
https://ncbi.nlm.nih.gov/pubmed/28508122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2167-6
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