Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in Hominoids

Urate oxidase (Uox) catalyses the first reaction of oxidative uricolysis, a three-step enzymatic pathway that allows some animals to eliminate purine nitrogen through a water-soluble compound. Inactivation of the pathway in hominoids leads to elevated levels of sparingly soluble urate and puts human...

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Vydáno v:Sci Rep
Hlavní autoři: Marchetti, Marialaura, Liuzzi, Anastasia, Fermi, Beatrice, Corsini, Romina, Folli, Claudia, Speranzini, Valentina, Gandolfi, Francesco, Bettati, Stefano, Ronda, Luca, Cendron, Laura, Berni, Rodolfo, Zanotti, Giuseppe, Percudani, Riccardo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138847/
https://ncbi.nlm.nih.gov/pubmed/27922051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38302
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