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PET Imaging of Dll4 Expression in Glioblastoma and Colorectal Cancer Xenografts Using (64)Cu-Labeled Monoclonal Antibody 61B

Delta-like ligand 4 (Dll4) expressed in tumor cells plays a key role to promote tumor growth of numerous cancer types. Based on a novel antihuman Dll4 monoclonal antibody (61B), we developed a (64)Cu-labeled probe for positron emission tomography (PET) imaging of tumor Dll4 expression. In this study...

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Detalles Bibliográficos
Publicado en:Mol Pharm
Main Authors: Zhou, Bin, Wang, Hui, Liu, Ren, Wang, Mengzhe, Deng, Huaifu, Giglio, Benjamin C., Gill, Parkash S., Shan, Hong, Li, Zibo
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444668/
https://ncbi.nlm.nih.gov/pubmed/26288060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00105
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