DNA-methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

In spite of both having features of germinal center B-cells, Burkitt lymphomas and follicular lymphomas are biologically and clinically quite diverse. We here performed whole genome bisulfite, genome and transcriptome sequencing from 13 IG-MYC-translocation positive Burkitt lymphoma, 9 BCL2-transloc...

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Udgivet i:Nat Genet
Main Authors: Kretzmer, Helene, Bernhart, Stephan H., Wang, Wei, Haake, Andrea, Weniger, Marc A., Bergmann, Anke K., Betts, Matthew J., Carrillo-de-Santa-Pau, Enrique, Doose, Gero, Gutwein, Jana, Richter, Julia, Hovestadt, Volker, Huang, Bingding, Rico, Daniel, Jühling, Frank, Kolarova, Julia, Lu, Qianhao, Otto, Christian, Wagener, Rabea, Arnolds, Judith, Burkhardt, Birgit, Claviez, Alexander, Drexler, Hans G., Eberth, Sonja, Eils, Roland, Flicek, Paul, Haas, Siegfried, Humme, Michael, Karsch, Dennis, Kerstens, Hinrik H.D., Klapper, Wolfram, Kreuz, Markus, Lawerenz, Chris, Lenzek, Dido, Loeffler, Markus, López, Cristina, MacLeod, Roderick A.F., Martens, Joost H.A., Kulis, Marta, Martín-Subero, José Ignacio, Möller, Peter, Nage, Inga, Picelli, Simone, Vater, Inga, Rohde, Marius, Rosenstiel, Philip, Rosolowski, Maciej, Russell, Robert B., Schilhabel, Markus, Schlesner, Matthias, Stadler, Peter F., Szczepanowski, Monika, Trümper, Lorenz, Stunnenberg, Hendrik G., Küppers, Ralf, Ammerpohl, Ole, Lichter, Peter, Siebert, Reiner, Hoffmann, Steve, Radlwimmer, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444523/
https://ncbi.nlm.nih.gov/pubmed/26437030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3413
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