metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data

The detection of differentially methylated regions (DMRs) is a necessary prerequisite for characterizing different epigenetic states. We present a novel program, metilene, to identify DMRs within whole-genome and targeted data with unrivaled specificity and sensitivity. A binary segmentation algorit...

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Veröffentlicht in:Genome Res
Hauptverfasser: Jühling, Frank, Kretzmer, Helene, Bernhart, Stephan H., Otto, Christian, Stadler, Peter F., Hoffmann, Steve
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728377/
https://ncbi.nlm.nih.gov/pubmed/26631489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.196394.115
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