Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase

PER β-lactamases are an emerging family of extended-spectrum β-lactamases (ESBL) found in Gram-negative bacteria. PER β-lactamases are unique among class A enzymes as they possess an inverted omega (Ω) loop and extended B3 β-strand. These singular structural features are hypothesized to contribute t...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Ruggiero, Melina, Papp-Wallace, Krisztina M., Taracila, Magdalena A., Mojica, Maria F., Bethel, Christopher R., Rudin, Susan D., Zeiser, Elise T., Gutkind, Gabriel, Bonomo, Robert A., Power, Pablo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444126/
https://ncbi.nlm.nih.gov/pubmed/28348157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02476-16
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