Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expression is...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shebzukhov, Yury V., Stanislawiak, Silke, Bezhaeva, Taisiya R., Nedospasov, Sergei A., Kuprash, Dmitry V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443812/
https://ncbi.nlm.nih.gov/pubmed/28539628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02553-y
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