Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun's ac...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Smeal, T, Binetruy, B, Mercola, D, Grover-Bardwick, A, Heidecker, G, Rapp, U R, Karin, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364600/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1630458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.8.3507-3513.1992
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