Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun'...

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Hlavní autoři: Smeal, T, Binetruy, B, Mercola, D, Grover-Bardwick, A, Heidecker, G, Rapp, U R, Karin, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC364600/
https://ncbi.nlm.nih.gov/pubmed/1630458
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