Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun'...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Smeal, T, Binetruy, B, Mercola, D, Grover-Bardwick, A, Heidecker, G, Rapp, U R, Karin, M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1992
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364600/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1630458/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.8.3507
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg