Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Vaccin Immunother
Hauptverfasser: Larson, Sarah M., Truscott, Laurel C., Chiou, Tzu-Ting, Patel, Amie, Kao, Roy, Tu, Andy, Tyagi, Tulika, Lu, Xiang, Elashoff, David, De Oliveira, Satiro N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443385/
https://ncbi.nlm.nih.gov/pubmed/28059624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2016.1268745
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