1,25-(OH)(2)D(3) and its analogue BXL-628 inhibit high glucose-induced activation of RhoA/ROCK pathway in HK-2 cells

It has previously been reported that 1,25-(OH)(2)D(3) inhibits high glucose-induced epithelial-to-mesenchymal transition (EMT) in HK-2 cells. However, the mechanism of this renoprotective action remains unclear. Elocalcitol (BXL-628), a vitamin D analog, has been suggested to be effective on the Rho...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Exp Ther Med
Main Authors: Zhang, Wei, Yi, Bin, Zhang, Ke, Li, Aimei, Yang, Shikun, Huang, Jing, Liu, Jishi, Zhang, Hao
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2017
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443178/
https://ncbi.nlm.nih.gov/pubmed/28565795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.4211
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