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Molecular basis for amyloid fibril formation and stability

The molecular structure of the amyloid fibril has remained elusive because of the difficulty of growing well diffracting crystals. By using a sequence-designed polypeptide, we have produced crystals of an amyloid fiber. These crystals diffract to high resolution (1 Å) by electron and x-ray diffracti...

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Autors principals: Makin, O. Sumner, Atkins, Edward, Sikorski, Pawel, Johansson, Jan, Serpell, Louise C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC544296/
https://ncbi.nlm.nih.gov/pubmed/15630094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406847102
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