Chloroquine inhibits Ca(2+) permeable ion channels-mediated Ca(2+) signaling in primary B lymphocytes

BACKGROUND: Chloroquine, a bitter tastant, inhibits Ca(2+) signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear. RESULTS: In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca(2+) increases in mouse splenic prima...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Biosci
Auteurs principaux: Wu, Yi-Fan, Zhao, Ping, Luo, Xi, Xu, Jin-Chao, Xue, Lu, Zhou, Qi, Xiong, Mingrui, Shen, Jinhua, Peng, Yong-Bo, Yu, Meng-Fei, Chen, Weiwei, Ma, Liqun, Liu, Qing-Hua
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442594/
https://ncbi.nlm.nih.gov/pubmed/28546857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-017-0155-5
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