Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice

In addition to motor function, the cerebellum has been implicated in cognitive and social behaviors. Various structural and functional abnormalities of Purkinje cells (PCs) have been observed in schizophrenia and autism. As PCs express the gene Disrupted-In-Schizophrenia-1 (DISC1), and DISC1 variant...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Neurobiol Dis
Main Authors: Shevelkin, Alexey V., Terrillion, Chantelle E., Abazyan, Bagrat N., Kajstura, Tymoteusz J., Jouroukhin, Yan A., Rudow, Gay L., Troncoso, Juan C., Linden, David J., Pletnikov, Mikhail V.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442447/
https://ncbi.nlm.nih.gov/pubmed/28392471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.04.008
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares