Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice

In addition to motor function, the cerebellum has been implicated in cognitive and social behaviors. Various structural and functional abnormalities of Purkinje cells (PCs) have been observed in schizophrenia and autism. As PCs express the gene Disrupted-In-Schizophrenia-1 (DISC1), and DISC1 variant...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Shevelkin, Alexey V., Terrillion, Chantelle E., Abazyan, Bagrat N., Kajstura, Tymoteusz J., Jouroukhin, Yan A., Rudow, Gay L., Troncoso, Juan C., Linden, David J., Pletnikov, Mikhail V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442447/
https://ncbi.nlm.nih.gov/pubmed/28392471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.04.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados