GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase as a previously unknown substrate of GCN2 in vitro wi...

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Publicado no:Sci Rep
Main Authors: Jaspart, A., Calmels, C., Cosnefroy, O., Bellecave, P., Pinson, P., Claverol, S., Guyonnet-Dupérat, V., Dartigues, B., Benleulmi, M. S., Mauro, E., Gretteau, P. A., Parissi, V., Métifiot, M., Andreola, M. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442153/
https://ncbi.nlm.nih.gov/pubmed/28536474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02276-0
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