Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the mechanism through which epigenetic regulation modulates intestinal epithelial integrity remains largely undefined. Here we show that EZH2, the catalytic subunit of polycomb repressive complex (PRC2), is...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Yongfeng, Peng, Junjie, Sun, Tongyu, Li, Ni, Zhang, Le, Ren, Jiale, Yuan, Huairui, Kan, Shan, Pan, Qiang, Li, Xiang, Ding, Yufeng, Jiang, Min, Cong, Xiaoji, Tan, Minjia, Ma, Yushui, Fu, Da, Cai, Sanjun, Xiao, Yichuan, Wang, Xiaoming, Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441742/
https://ncbi.nlm.nih.gov/pubmed/28439030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700909114
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