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Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin
Accumulating evidence supports the gain-of-function of mutant forms of p53 (mutp53s). However, whether mutp53 directly perturbs the DNA replication checkpoint remains unclear. Previously, we have demonstrated that TopBP1 forms a complex with mutp53s and mediates their gain-of-function through NF-Y a...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5441733/ https://ncbi.nlm.nih.gov/pubmed/28439015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619832114 |
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