Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

CD40 is an interesting target in cancer immunotherapy due to its ability to stimulate T-helper 1 immunity via maturation of dendritic cells and to drive M2 to M1 macrophage differentiation. Pancreatic cancer has a high M2 content that has shown responsive to anti-CD40 agonist therapy and CD40 may th...

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Foilsithe in:Gene Ther
Main Authors: Eriksson, E, Moreno, R, Milenova, I, Liljenfeldt, L, Dieterich, L C, Christiansson, L, Karlsson, H, Ullenhag, G, Mangsbo, S M, Dimberg, A, Alemany, R, Loskog, A
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441514/
https://ncbi.nlm.nih.gov/pubmed/27906162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.80
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