An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

The molecular mechanism through which the interaction of a clonotypic αβ T-cell receptor (TCR) with a peptide-loaded major histocompatibility complex (p/MHC) leads to T-cell activation is not yet fully understood. Here we exploit a high-affinity TCR (B4.2.3) to examine the structural changes that ac...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Natarajan, Kannan, McShan, Andrew C., Jiang, Jiansheng, Kumirov, Vlad K, Wang, Rui, Zhao, Huaying, Schuck, Peter, Tilahun, Mulualem E., Boyd, Lisa F., Ying, Jinfa, Bax, Ad, Margulies, David H., Sgourakis, Nikolaos G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440810/
https://ncbi.nlm.nih.gov/pubmed/28508865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15260
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