An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

The molecular mechanism through which the interaction of a clonotypic αβ T-cell receptor (TCR) with a peptide-loaded major histocompatibility complex (p/MHC) leads to T-cell activation is not yet fully understood. Here we exploit a high-affinity TCR (B4.2.3) to examine the structural changes that ac...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Natarajan, Kannan, McShan, Andrew C., Jiang, Jiansheng, Kumirov, Vlad K, Wang, Rui, Zhao, Huaying, Schuck, Peter, Tilahun, Mulualem E., Boyd, Lisa F., Ying, Jinfa, Bax, Ad, Margulies, David H., Sgourakis, Nikolaos G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440810/
https://ncbi.nlm.nih.gov/pubmed/28508865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15260
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