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Studies of the properties of human origin recognition complex and its Walker A motif mutants

The eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex. In this report we describe the isolation of the wild-type Homo sapiens (Hs)ORC and variants containing a Walker A motif mutation in the Orc1, Orc4,...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Giordano-Coltart, Jennifer, Ying, Carol Y., Gautier, Jean, Hurwitz, Jerard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544074/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15618391/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408690102
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