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In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

The relatively recent discovery and characterization of human broadly neutralizing antibodies (bnAbs) against influenza virus provide valuable insights into antiviral and vaccine development. However, the factors that influence the evolution of high-affinity bnAbs remain elusive. We therefore explor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wu, Nicholas C., Grande, Geramie, Turner, Hannah L., Ward, Andrew B., Xie, Jia, Lerner, Richard A., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440694/
https://ncbi.nlm.nih.gov/pubmed/28504265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15371
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